Characterization of the murine phosphatidylethanolamine N-methyltransferase-2 gene
نویسندگان
چکیده
منابع مشابه
Characterization of the murine phosphatidylethanolamine N-methyltransferase-2 gene.
Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in the mammalian liver via three sequential methylations. In the present studies, we cloned and characterized the murine gene for PEMT2, the isoform of the enzyme that localized to the mitochondria-associated membrane. The structure of the gene was determined by analys...
متن کاملDiminished expression of phosphatidylethanolamine N-methyltransferase 2 during hepatocarcinogenesis.
Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine into phosphatidylcholine. At least two forms of PEMT are present in hepatocytes. However, PEMT activity is negligible in two hepatoma cell lines. Previous studies have indicated an inverse relationship between the expression of one form, PEMT2, and the rate of liver growth, sugg...
متن کاملFunctional analysis of two isoforms of phosphatidylethanolamine N-methyltransferase.
The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). In the present study, to compare the functions of the two isoforms of PEMT, we established HEK (human embryonic kidney)-293 cell lines stably expressing PEMT-L and PEMT-S....
متن کاملWhy has phosphatidylethanolamine N-methyltransferase survived in evolution?
Lipid Group Colloquium Organized and Edited by D. C. Wilton (Department of Biochemistry, University of Southampton) and A. Postle (Department of Child Health, Southampton General Hospital) and Sponsored by Yamanouchi Research Institute, Sigma-Aldrich Company, British Biotechnology Group, Celltech Therapeutics, Micrornass (UK) and Pharrnacia and Upjohn. 665th Meeting held at Southampton, 3 I Mar...
متن کاملPhosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes.
Choline is an essential nutrient for humans, though some of the requirement can be met by endogenous synthesis catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). Premenopausal women are relatively resistant to choline deficiency compared with postmenopausal women and men. Studies in animals suggest that estrogen treatment can increase PEMT activity. In this study we investigated ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1996
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)37483-6